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M9630604.TXT
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1996-02-27
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Document 0604
DOCN M9630604
TI A comparison of cerebral SPECT abnormalities in HIV-positive homosexual
men with and without cognitive impairment.
DT 9603
AU Sacktor N; Van Heertum RL; Dooneief G; Gorman J; Khandji A; Marder K;
Nour R; Todak G; Stern Y; Mayeux R; Gertrude H. Sergievsky Center,
Columbia University College of; Physicians and Surgeons, New York, NY,
USA.
SO Arch Neurol. 1995 Dec;52(12):1170-3. Unique Identifier : AIDSLINE
MED/96094927
AB OBJECTIVE: To determine whether technetium Tc 99m exametazime (HMPAO)
single-photon emission computed tomography (SPECT) can distinguish
between human immunodeficiency virus (HIV)-positive homosexual men with
normal neuropsychologic test results and HIV-positive homosexual men
with abnormal neuropsychologic test results. DESIGN: Neurologic,
neuropsychologic, magnetic resonance imaging, and Tc 99m HMPAO SPECT
examinations were performed on 10 HIV-positive homosexual men without
cognitive impairment and five HIV-positive homosexual men with cognitive
impairment. PATIENTS: Human immunodeficiency virus-positive homosexual
men from New York City were recruited for the study. MAIN OUTCOME
MEASURES: Findings on SPECT scans were evaluated qualitatively for focal
defects, heterogeneity of the cortical margin, white matter
hypoperfusion, and decreased global cortical uptake. All SPECT focal
defects were coregistered with magnetic resonance images; SPECT
heterogeneity and global cortical uptake were also measured
quantitatively. RESULTS: Coregistration with magnetic resonance imaging
revealed that 63% of the focal SPECT defects corresponded to brain gyri
and 37% corresponded to sulci. There was no significant difference in
the frequency of qualitative or quantitative SPECT abnormalities between
HIV-positive homosexual men ith and without cognitive impairment.
However, after examining individual neuropsychologic test factors,
impaired motor speed performance was associated with decreased
quantitative global cerebral uptake. CONCLUSIONS: Qualitative SPECT
abnormalities are not increased in frequency in HIV-positive homosexual
men with global cognitive impairment compared with those in HIV-positive
homosexual men without cognitive impairment. Impaired motor speed
performance may be associated with decreased quantitative global
cerebral uptake.
DE Adult Brain/PATHOLOGY/*RADIONUCLIDE IMAGING Cognition
Disorders/DIAGNOSIS/ETIOLOGY/*RADIONUCLIDE IMAGING Comparative Study
*Homosexuality, Male Human HIV
Infections/*COMPLICATIONS/PSYCHOLOGY/RADIONUCLIDE IMAGING Linear Models
Magnetic Resonance Imaging Male Middle Age Neuropsychological Tests
Organotechnetium Compounds/DIAGNOSTIC USE Oximes/DIAGNOSTIC USE
Psychomotor Performance Support, Non-U.S. Gov't Support, U.S. Gov't,
P.H.S. Tomography, Emission-Computed, Single-Photon JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).